Neurology Medicine

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The caspases are a group of cysteine protease enzymes essential to apoptosis, inflammation and necrosis. Caspase 3 has been identified as one of the key mediators of apoptosis.

Human caspases form three distinct groups: cytokine activators, which are involved with cytokine processing and the inflammatory response, and apoptosis initiators and activators (also called executioners). Caspase 3, 6 and 7 are executioners, while caspases 2, 8, 9 and 10 are all initiators.

Caspases are expressed as inactive pro-enzymes, activated by proteolytic cleavage in response to apoptotic stimuli. Using caspase antibodies, scientists have shown caspase 3, 8 and 9 to be expressed at pivotal sites of the apoptosis pathway, mediating disassembly of the cell. Caspase 8 initiates this, as part of a complex, in response to extracellular ligand signaling in association with death domain receptors. Caspase 9 then activates cellular disassembly, in response to signals which initiate mitochondrial cytochrome c release, forming a complex with extra-mitochondrial cytochrome c and APAF-1.

Caspase 3 antibody studies have revealed caspase 3 regulates and amplifies caspase 8 and 9 activity. Caspase 3 is activated by caspase 8 and 9, following which it cleaves other proteins, including other caspases. We at Novus Biologicals have an extensive antibody database which is helping researchers to extend and refine knowledge of the caspase cascade.

Alternative Names
Coronary artery disease (CAD), coronary artery disease or coronary artery disease, coronary heart disease (CHD), heart disease or arteriosclerotic heart disease

Definition
Is a narrowing of small blood vessels that supply blood and oxygen to the heart. This disease is also called coronary artery disease.

Causes, incidence and risk factors
Coronary heart disease is usually caused by a condition called atherosclerosis, which occurs when fatty material and a substance called plaque builds up on artery walls, which causes them to constrict. As the coronary arteries narrow, blood flow to the heart can slow or stop, causing chest pain (stable angina), shortness of breath, heart attack or other symptoms. Read the rest of this entry »

Advances in CT diagnosis allows, early invasive procedures and reduce disease

Knowing the risk of a heart attack, detect tumors more accurately, quickly locate blockages in the arteries, making virtual colonoscopy, are some of the tests can be performed with the new 64-slice Multidetector Tomography Hospital Herrera Llerandi

· First hospital in Guatemala with 64-slice Multidetector Tomography, Siemens Somatom Sensation, which allows more accurate diagnosis and novel applications in heart, arteries, pediatrics, oncology and other

· One of the most innovative tests that allows the CT scanner is the heart (coronary arteriography) and calcium score of the arteries, which measures the risk of heart attacks in the coming years Read the rest of this entry »